This chart breaks down common reasons people look into peptides, along with the underlying mechanisms behind them. It’s designed as a quick reference, not a treatment guide.
| Issue / Problem | Peptide(s) | Reasoning |
|---|---|---|
| Constant hunger / cravings | Retatrutide, Tirzepatide, Semaglutide | GLP-1 / GIP / glucagon activity reduces appetite and slows gastric emptying |
| Difficulty losing bodyweight | Retatrutide, Tirzepatide | Broad metabolic effects including appetite suppression and increased energy expenditure |
| Hard-to-lose fat | AOD-9604 | GH fragment associated with lipolysis without full GH signaling |
| Slow fat metabolism | 5-Amino-1MQ | Inhibits NNMT, linked to improved metabolic efficiency |
| Low energy / fatigue | MOTS-c, NAD+ | Supports mitochondrial function and cellular energy production |
| Poor endurance | MOTS-c | Improves metabolic flexibility and fatigue resistance |
| Low GH output | Ipamorelin, CJC-1295 | Stimulates endogenous GH release via GHRH and ghrelin pathways |
| Muscle growth plateau | IGF-1 LR3 | Promotes muscle cell growth and nutrient uptake |
| Slow muscle repair | IGF-1 LR3, PEG-MGF | Supports satellite cell activation and tissue repair |
| Weak recovery between workouts | CJC-1295, Ipamorelin | Increases GH pulses to improve recovery |
| Frequent injuries | BPC-157, TB-500 | Promotes tissue repair and blood flow |
| Tendon pain | BPC-157 | Supports collagen formation and tendon repair signaling |
| Ligament issues | BPC-157, TB-500 | Enhances connective tissue healing |
| Joint stiffness | BPC-157 | Supports joint recovery and inflammation control |
| Chronic inflammation | KPV, BPC-157 | Modulates inflammatory signaling pathways |
| Gut issues / digestion | BPC-157 | Supports gut lining integrity |
| Skin aging / wrinkles | GHK-Cu | Stimulates collagen and skin remodeling |
| Hair thinning | GHK-Cu | Supports follicle health and growth signaling |
| Skin healing | GHK-Cu, BPC-157 | Enhances tissue regeneration |
| Collagen loss | GHK-Cu | Upregulates collagen production pathways |
| Poor sleep onset | DSIP | Interacts with sleep-regulating neuropeptides |
| Low sleep quality | DSIP, Epitalon | Influences circadian rhythm and sleep depth |
| Irregular sleep schedule | Epitalon | Linked to melatonin regulation |
| Aging / longevity focus | Epitalon, NAD+ | Associated with cellular repair and aging pathways |
| Brain fog | Semax | Influences BDNF and dopamine pathways |
| Low motivation / focus | Semax | Supports neurotransmitter activity related to focus |
| Anxiety / stress | Selank | Affects GABA-related calming pathways |
| Memory issues | Dihexa | Associated with synaptic growth and neuroplasticity |
| Weak immune response | Thymosin Alpha-1 | Modulates immune cell activity |
| Antimicrobial support | LL-37 | Part of innate immune defense mechanisms |
| Metabolic dysfunction | Retatrutide, Tirzepatide | Improves insulin signaling and metabolic regulation |
| Insulin resistance | Tirzepatide | Enhances insulin sensitivity via incretin pathways |
| Blood sugar instability | Semaglutide, Tirzepatide | Slows glucose release and improves insulin response |
| Low mitochondrial function | SS-31, MOTS-c | Supports mitochondrial efficiency |
| Fatigue under stress | SS-31 | Supports cellular energy under oxidative stress |
| Poor workout pumps | IGF-1 LR3 | Enhances nutrient delivery and vascular response |
| Difficulty staying lean | 5-Amino-1MQ | Supports reduced fat accumulation |
| Abdominal fat accumulation | Tesamorelin | Stimulates GH affecting visceral fat metabolism |
| GH-related decline | CJC-1295, Ipamorelin, Tesamorelin | Stimulates endogenous GH production |
| Low libido | PT-141, Kisspeptin | Influences reproductive hormone signaling |
| Skin pigmentation / tanning | Melanotan II | Increases melanin production |
| Overtraining symptoms | CJC-1295, Ipamorelin, TB-500 | Supports recovery and systemic repair |
| Soft tissue damage | BPC-157, TB-500 | Supports repair of muscle and connective tissue |
Disclaimer: This content is for informational purposes only and does not constitute medical advice. These compounds are not approved in Canada for the uses described.